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You should know that your mental health may change in unexpected ways when you take paroxetine or other antidepressants to treat depression or other mental illness even if you are an adult over 24 years of ageYou may also experience changes in your mental health if you are a woman taking a low dose of paroxetine to treat hot flashes and you have never had depression or another mental illnessYou may become suicidalespecially at the beginning of your treatment and any time that your dose is increased or decreasedYouyour familyor your caregiver should call your doctor right away if you experience any of the following symptomsnew or worsening depressionthinking about harming or killing yourselfor planning or trying to do soextreme worryagitationpanic attacksdifficulty falling asleep or staying asleepaggressive behaviorirritabilityacting without thinkingsevere restlessnessand frenzied abnormal excitementBe sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

The Brisdelle brand of paroxetine is used to treat hot flashes related to menopauseBrisdelle is not for treating any other conditions.

CommentsThe daily dose may be increased in 12.5 mg increments at weekly intervalsaccording to clinical response and tolerability.

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based on the assumption that the relationship between paroxetine s in vitro ki and its lack of effect on terfenadine s in vivo clearance predicts its effect on other 3a4 substrates, paroxetine s extent of inhibition of cyp3a4 activity is not likely to be of clinical significance.

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