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Hypocalcemia can nullify the effects of digoxin in humansthusdigoxin may be ineffective until serum calcium is restored to normalThese interactions are related to the fact that digoxin affects contractility and excitability of the heart in a manner similar to that of calcium.

The balance of certain natural minerals in your bloodcalciummagnesiumpotassiumcan affect how this drug works in your bodyCertain drugs such aswater pillsdiureticsmay affect the normal balance of these mineralsTell your doctor or pharmacist if you are taking awater pillor if you have a history of mineral imbalanceAsk your doctor or pharmacist whether you should take a nutritional supplement or follow a special diet.

Newborn infants display considerable variability in their tolerance to digoxinPremature and immature infants are particularly sensitive to the effects of digoxinand the dosage of the drug must not only be reduced but must be individualized according to their degree of maturity.

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