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Morphine; naltrexone major concomitant use of hydrocodone with morphine may lead to hypotension, profound sedation, coma, respiratory depression and death.

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In view of the lack of actual experience in the treatment of REVIA overdosepatients should be treated symptomatically in a closely supervised environmentPhysicians should contact a poison control center for the most up-to-date information.

Irrespective of the drug chosen to reverse REVIA blockadethe patient should be monitored closely by appropriately trained personnel in a setting equipped and staffed for cardiopulmonary resuscitation.

Naltrexone may cause liver damage when taken in large dosesIt is not likely that naltrexone will cause liver damage when taken in recommended dosesTell your doctor if you have or have ever had hepatitis or liver diseaseIf you experience any of the following symptomsstop taking naltrexone and call your doctor immediatelyexcessive tiredness,unusual bleeding or bruisingloss of appetitepain in the upper right part of your stomach that lasts more than a few dayslight-colored bowel movements,dark urineor yellowing of the skin or eyes.

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prophylactic measures the naltrexone program is the best option to prevent a relapse to opioid use.

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