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There is an enhanced corticosteroid effect in patients with hypothyroidism and in those with cirrhosis.

Aspirin should be used cautiously in conjunction with corticosteroids in patients with hypoprothrombinemia.

BECAUSE OF ITS MARKED EFFECT ON SODIUM RETENTIONTHE USE OF FLUDROCORTISONE ACETATE IN THE TREATMENT OF CONDITIONS OTHER THAN THOSE INDICATED HEREIN IS NOT ADVISED

Corticosteroids are contraindicated in patients with systemic fungal infections and in those with a history of possible or known hypersensitivity to these agents.

Patients should not be vaccinated against smallpox while on corticosteroid therapyOther immunization procedures should not be undertaken in patients who are on corticosteroidsespecially on high dosebecause of possible hazards of neurological complications and a lack of antibody response.

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