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Premarin conjugated estrogens tablets for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares urine.

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Safety and effectiveness in pediatric patients have not been establishedEstrogen treatment of prepubertal girls induces premature breast development and vaginal cornificationand may induce uterine bleeding.

Stop using vaginal conjugated estrogens and call your doctor at once if you have a serious side effect such as:

Other binding proteins may be elevated in serumi.ecorticosteroid binding globulinCBGsex hormone-binding globulinSHBGleading to increased circulating corticosteroid and sex steroidsrespectivelyFree or biologically active hormone concentrations may be decreased.

This medication must not be used during pregnancyIf you become pregnant or think you may be pregnanttell your doctor right away.

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