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The Coxib and traditional NSAID TrialistsCollaboration meta-analysis of randomized controlled trials demonstrated an approximately two-fold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patientsIn a Danish National Registry study of patients with heart failureNSAID use increased the risk of MIhospitalization for heart failureand death.

A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polypsseverepotentially fatal bronchospasmand/or intolerance to aspirin and other NSAIDsBecause cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patientsPonstel is contraindicated in patients with this form of aspirin sensitivitysee CONTRAINDICATIONSWhen Ponstel is used in patients with pre-existing asthmawithout known aspirin sensitivitymonitor patients for changes in the signs and symptoms of asthma.

The mechanism of action of Ponstellike that of other NSAIDsis not completely understood but involves inhibition of cyclooxygenaseCOX-1 and COX-2

Tell your doctor right away if any of these unlikely but serious side effects occurfaintingpersistent/severe headachehearing changese.gringing in the earsfast/pounding heartbeatmental/mood changesstomach paindifficult/painful swallowingvision changessymptoms of heart failuresuch as swelling ankles/feetunusual tirednessunusual/sudden weight gain

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generic ponstel is in a group of drugs called nonsteroidal anti-inflammatory drugs nsaids .

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