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Methylprednisolone acetatea slightly soluble ester of methylprednisoloneis capable of producing a more prolonged local anti-inflammatory effect than equimolar doses of hydrocortisone acetateFollowing intrasynovial injectionrelief from pain may be experienced within 12 to 24 hoursThe duration of relief variesbut averages three to four weekswith a range of one to five or more weeksInjections of methylprednisolone acetate have been well toleratedIntrasynovialintra-articularinjections may occasionally result in an increased localized inflammatory response.

The most commonly occurring side effects have included fluid retentionalteration in glucose toleranceincreased blood pressurebehavioral and mood changesincreased appetiteand weight gainthe incidence generally correlates with dosagetiming of administrationand duration of treatmentRef]

Frequency not reportedMenstrual irregularitiesincreased or decreased motility and number of spermatozoaincreased urine calciumglycosuriaRef]

Contraindicatii Infectii sistemice cu fungiHipersensibilitate cunoscuta la Medrol tablete sau metilprednisolon.

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