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, associated with nephrotic syndrome the effect of lasix may be weakened and its ototoxicity potentiated.

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Methotrexate and other drugs thatlike LASIXundergo significant renal tubular secretion may reduce the effect of LASIXConverselyLASIX may decrease renal elimination of other drugs that undergo tubular secretionHigh-dose treatment of both LASIX and these other drugs may result in elevated serum levels of these drugs and may potentiate their toxicity as well as the toxicity of LASIX.

The principal signs and symptoms of overdose with LASIX are dehydrationblood volume reductionhypotensionelectrolyte imbalancehypokalemia and hypochloremic alkalosisand are extensions of its diuretic action.

The concentration of LASIX in biological fluids associated with toxicity or death is not known.

LASIX may decrease arterial responsiveness to norepinephrineHowevernorepinephrine may still be used effectively.

Signs of liver or pancreas problemsloss of appetiteupper stomach painthat may spread to your backnausea or vomitingdark urinejaundiceyellowing of the skin or eyes

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from a paper published in jama, no cases of first dose syncope were seen in over 1100 patients given only 1mg of prazosin at bedtime with avoidance of diuretics lasix furosemide, hctz hydrochlorothiazide, bumetanide bumex, spironolactone or other antihypertensive agents beta blockers — ends in -olol or -alol or -ilol, calcium channel blockers etc on the day prior to initiation of therapy.

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